Reducing Yeast and Bacteria Contact May Decline Childhood Dental Caries

Reducing Yeast and Bacteria Contact May Decline Childhood Dental Caries

Philadelphia, USA-  A team at the University of Pennsylvania School of Dental Medicine have found that Candida albicans, a type of yeast, may work in tandem with harmful bacertia such as Streptococcus mutans which is the primary actor in dental caries. This can help encourage the formation of early childhood caries. 

A study that was conducted previously discovered that interaction between Candida albicans and an enzyme produced by S. mutans leads to the development of a form of biofilm. In the new research the team discovered which of Candida albicans surface molecules engage with the enyzme to produce this biofilm. Prof. Hyun (Michel) Koo, of the university’s Department of Orthodontics and divisions of Pediatric Dentistry and Community Oral Health, was the lead author of the study and explained that stopping this interaction may help to combat resultant caries.

Koo said that instead of just targeting bacteria to treat early childhood cares, they might also want to target the fungi. He said that their data provided hints that they might not need to use a broad spectrurm antimicrobial and might be able to target the enzyme or cell wall of the fungi to disrupt the plaque biofilm formation. 

The main way that dental biolfim is created by young children is by the consumption of high-sugar foods and beverages. This is because Candida albicans is only able to bind with S.mutans and form plaque in the presence of sugar.



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